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Watch Carefully (one)pentobarbital will lessen the level or influence of benzhydrocodone/acetaminophen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Warning when discontinuing CYP3A4 inducers which might be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may improve and can lead to potentially deadly respiratory melancholy.

pentobarbital will lower the level or outcome of clozapine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

Contraindicated (1)pentobarbital will minimize the level or outcome of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with powerful CYP3A4 inducers is just not encouraged

pentobarbital will decrease the extent or effect of stiripentol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. If struggling to stay away from coadministration of stiripentol with robust CYP3A4 inducers, enhance stiripentol dose.

pentobarbital will lower the extent or outcome of ramelteon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.

Monoamine oxidase inhibitors (MAOI) could get more info inhibit barbiturate metabolism and prolong barbiturate effects; keep track of carefully

Withdrawal indicators manifest in infants born to mothers who obtain barbiturates all over the past trimester of pregnancy

Check Intently (2)pentobarbital will lower the extent or effect of buprenorphine, prolonged-performing injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. People who transfer to buprenorphine lengthy-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers really should be monitored to make sure buprenorphine plasma amounts are enough.

pentobarbital decreases amounts of toremifene by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. CYP3A4 inducers increase level of toremifene metabolism, decreasing the constant-state focus in serum.

Barbiturates could cause fetal damage when administered into a pregnant female; retrospective, situation-managed reports have proposed a connection involving maternal intake of barbiturates and the next-than-anticipated incidence of fetal abnormalities

pentobarbital will lessen the extent or impact of etonogestrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

pentobarbital will minimize the extent or result of amlodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

pentobarbital will lessen the extent or outcome of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Pitolisant exposure is lowered by fifty% if coadministered with solid CYP3A4 inducers.

benzhydrocodone/acetaminophen and pentobarbital both boost sedation. Stay away from or Use Alternate Drug. Limit use to people for whom substitute therapy possibilities are inadequate